Naphazoline nasal drops in pregnancy

Medically reviewed by Drugs. Written by Cerner Multum. Naphazoline nasal is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion stuffy nose.

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Naphazoline nasal for the nose is for temporary relief of stuffy nose caused by hay feverallergiesor the common cold. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Ask a doctor or pharmacist if it is safe for you to take naphazoline nasal if you have other medical conditions, especially:. It is not known whether naphazoline nasal will harm an unborn baby.

Do not use this medicine without a doctor's advice if you are pregnant. It is not known whether naphazoline nasal passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby. Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Using this medicine too long or too often may worsen your symptoms and cause damage to the blood vessels in your nose. Blow your nose gently. Keep your head upright and insert the tip of the bottle into one nostril. Press your other nostril closed with your finger. Breathe in quickly and gently spray the medicine into your nose.

Then use the spray in your other nostril.There's not enough data to completely rule out risk for most drugs in pregnancy for safety reasons, few studies test drugs in human pregnanciesbut I would rate nasal spray decongestants as low risk, with a couple of cautions.

The active ingredients in these products — ephedrine, epinephrine, naphazoline, oxymetazoline, phenylephrine, pseudoephedrine, tetrahydrozoline, and xylometazoline — are low risk, with one caveat: I would avoid using pseudoephedrine in the first trimester because of a possible link with abdominal birth defects. You'll also want to avoid long-term use of nasal spray decongestants. That's because after using them regularly for two or three days, you start to get rebound congestion that makes you worse off than you were before.

To avoid the rebound effect, try limiting your use of decongestants to nighttime, when congestion may make it hard to sleep. You can also try using a plain saline nose spray. Other options include rubbing a camphorated vapor rub ointment at the bottom of each nostril, or even eating a spicy meal. If congestion is still making you miserable, talk with your doctor about taking a prescription decongestant medication.

naphazoline nasal drops in pregnancy

In fact, it's a good idea to talk with your doctor about taking any over-the-counter medications during pregnancyto make sure all the ingredients in the product you're considering are safe for you and your baby.

Also talk with your doctor if you have signs of a sinus infection, such as a fever and yellow, green, or red mucus. A bacterial infection can release toxins into your bloodstream, which could be harmful for your pregnancy, so you'll want to treat it with antibiotics. Get more tips for relieving a stuffy nose during pregnancy. Join now to personalize. Photo credit: iStock. Featured video. Stuffy nose during pregnancy.

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Is it safe to take ibuprofen during pregnancy? New to BabyCenter? Join now.Generic Name: Naphazoline hydrochloride Dosage Form: ophthalmic solution. Medically reviewed by Drugs. Last updated on Oct 22, Naphazoline Hydrochloride, an ocular vasoconstrictor, is an imidazoline derivative sympathomimetic amine. It occurs as a white, odorless crystalline powder having a bitter taste and is freely soluble in water and in alcohol.

The active ingredient is represented by the structural formula:. Preservative: Benzalkonium Chloride 0. Naphazoline constricts the vascular system of the conjunctiva. It is presumed that this effect is due to direct stimulation of the drug upon the alpha adrenergic receptors in the arterioles of the conjunctiva resulting in decreased conjunctival congestion.

Naphazoline belongs to the imidazoline class of sympathomimetics.

naphazoline nasal drops in pregnancy

Naphazoline Hydrochloride Ophthalmic Solution is indicated for use as a topical ocular vasoconstrictor. Contraindicated in the presence of an anatomically narrow angle or in narrow angle glaucoma or in persons who have shown hypersensitivity to any component of this preparation.

Patients under therapy with MAO inhibitors may experience a severe hypertensive crisis if given a sympathomimetic drug. Use in children, especially infants, may result in CNS depression leading to coma and marked reduction in body temperature. General: For topical ophthalmic use only.


Use with caution in presence of hypertension, cardiovascular abnormalities, hyperglycemia diabeteshyperthyroidism, infection or injury. Patient Information: Patients should be advised to discontinue the drug and consult the physician if relief is not obtained within 48 hours of therapy, if irritation, blurring or redness persists or increases, or if symptoms of systemic absorption occur, i.

To prevent contaminating the dropper tip and solution, do not touch any surface, the eyelids or the surrounding area with the dropper tip of the bottle.

If solution changes color or becomes cloudy, do not use. Drug Interactions: Concurrent use of maprotiline or tricyclic antidepressants and Naphazoline may also potentiate the pressor effect of Naphazoline. Pregnancy Category C: Animal reproduction studies have not been conducted with Naphazoline. It is also not known whether Naphazoline can cause harm when administered to a pregnant women or can affect reproduction capacity. Naphazoline should be given to a pregnant women only if clearly needed.

Nursing Mothers: It is not known whether Naphazoline is excreted in human milk.

Is it safe to use a nasal spray decongestant during pregnancy?

Because many drugs are excreted in human milk, caution should be exercised when Naphazoline is administered to a nursing women. Pediatric Use: Safety and effectiveness in the pediatric population have not been established. Ocular: Mydriasis, increased redness, irritation, discomfort, blurring, punctate keratitis, lacrimation, increased intraocular pressure. Systemic: Dizziness, headache, nausea, sweating, nervousness, drowsiness, weakness, hypertension, cardiac irregularities, and hyperglycemia.

Instill one or two drops in the conjunctival sac s every three to four hours as needed. NDC The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs.Medically reviewed by Drugs. Last updated on Feb 18, Vasoconstrictor; an imidazoline-derivative sympathomimetic amine.

Temporary relief of conjunctival congestion, itching, and minor irritation. Used alone or in fixed combination with antihistamines e. Ineffective in the treatment of delayed hypersensitivity reactions such as contact dermatoconjunctivitis. Apply topically to nasal mucosa or to conjunctiva. Apply topically to the conjunctiva. Avoid contamination of the dropper tip. Some manufacturers recommend that contact lenses be removed before administering the ophthalmic solution. Do not administer discolored or cloudy solutions.

For self-medication1 or 2 drops of a 0.

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Self-medication : Not more frequently than every 6 hours; maximum duration of 3 days. Angle-closure glaucoma. Known hypersensitivity to naphazoline or any ingredient in the formulation.

Concomitant use with MAO inhibitor may result in severe hypertensive crisis. Possible headache, hypertension, cardiac irregularities, nervousness, nausea, dizziness, weakness, and sweating.

naphazoline nasal drops in pregnancy

Accidental ingestion of imidazoline derivatives i. Use not recommended in patients with glaucoma except under the advice and supervision of a physician.

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When used in fixed combination with antihistamines e. Not known whether naphazoline is distributed into milk.

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Safety and efficacy of 0. Accidental ingestion of OTC ophthalmic solutions or nasal sprays containing imidazoline derivatives i. Possible liberation of pigment granules, presumably from the iris following conjunctival application of naphazoline, especially high concentrations.

Possible severe hypertensive reaction c d. Occasionally, absorption may be sufficient to produce systemic effects. Local vasoconstriction usually occurs within 10 minutes. Local vasoconstriction may persist for 2—6 hours. Room temperature; protect from light. Constricts small arterioles and temporarily relieves conjunctival congestion following topical application.

Overuse of nasal solution may cause recurrence or exacerbation of nasal congestion; overuse of ophthalmic solution may produce increased redness of the eye. Importance of avoiding contamination of the dropper tip.

Importance of calling clinician or poison control center if accidentally ingested.Medically reviewed by Drugs. Last updated on Oct 8, Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. You must check to make sure that it is safe for you to take naphazoline nasal with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use naphazoline nasal as ordered by your doctor.

Read all information given to you. Follow all instructions closely. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:. All drugs may cause side effects. However, many people have no side effects or only have minor side effects.

Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Other brands: Privine. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Skip to Content. If you have an allergy to naphazoline or any other part of naphazoline nasal.

If you are allergic to naphazoline nasal ; any part of naphazoline nasal ; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems. What are some things I need to know or do while I take Naphazoline? Tell all of your health care providers that you take naphazoline nasal.

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This includes your doctors, nurses, pharmacists, and dentists. Do not use for more than 3 days.Food and Drug Administration FDA is warning the public that accidental ingestion swallowing by children of over-the-counter OTC; available without a prescription eye drops used to relieve redness and nasal decongestant sprays can result in serious harm.

The eye drops and nasal sprays that have been involved in the cases of accidental ingestion contain the active ingredients tetrahydrozoline, oxymetazoline, or naphazoline. These products are sold under various brand names, as generics, and as store brands see List of Products below.

Facts about OTC redness-relief eye drops and nasal decongestant sprays.

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The cases of accidental ingestion reviewed by FDA occurred in children 5 years of age and younger see Data Summary below. No deaths were reported; however, serious events requiring hospitalization such as coma, decreased heart rate, decreased breathing, and sedation sleepiness have occurred.

Ingestion of only a small amount mL; for reference, there are 5 mL in a teaspoon of the eye drops or nasal spray can lead to serious adverse events in young children. Most of these redness-relief eye drops and nasal decongestant sprays currently do not come packaged with child-resistant closures, so children can accidentally ingest the drug if the bottles are within easy reach.

Consumers should store these products out of reach of children at all times. To protect young children from ingesting these products, earlier this year the U. Additional Information for Health Care Professionals. The children ranged in age from 1 month to 5 years. Fifty-three cases reported hospitalization due to symptoms including nausea, vomiting, lethargy, tachycardia, decreased respiration, bradycardia, hypotension, hypertension, sedation, somnolence, mydriasis, stupor, hypothermia, drooling, and coma.

The cases reported that the children were either chewing or sucking on the bottles or were found with an empty bottle next to them.

In five cases, the children were found playing with the bottle; the case reports did not state if the children had ingested the drug, however they exhibited symptoms associated with ingestion of the products.

In four cases, the child gained access to the product by finding it in various places around his or her home. Sixty-two cases reported the name of the product that had been ingested; these cases included various tetrahydrozoline, oxymetazoline, and naphazoline products.

Naphazoline nasal

Thirty-one of the 62 cases also reported an amount of the product that was ingested. The amounts ranged from 0. An article in the medical literature by Spiller et al.Purpose: To investigate whether exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy was associated with an increased risk of malformations in humans.

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Methods: All women giving live birth between and in Denmark were included in this nationwide cohort study. All women redeeming at least one prescription of antazoline-naphazoline eye drops during the first 84 days of pregnancy were identified. Logistic regression was used to estimate the odds ratios of malformations among exposed offspring compared to non-exposed offspring. Results: We identified births between and A total of women 0. The rate of congenital malformations was 3.

First-trimester exposure to antazoline-naphazoline was not associated with major congenital malformations overall odds ratio: 0. Conclusion: Exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy appears not to be associated with increased teratogenic risk. Keywords: antazoline-naphazoline; eye drops; pregnancy; safety; topical.

Abstract Purpose: To investigate whether exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy was associated with an increased risk of malformations in humans. Publication types Multicenter Study.

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